Pandemics. The word conjures up images of horrific diseases sweeping the globe and killing everyone in their path. But such highly lethal illnesses almost never create pandemics. The reality is deadly serious but far more subtle.

In Pandemics: What Everyone Needs to Know®, Peter Doherty, who won the Nobel Prize for his work on how the immune system recognizes virus-infected cells, offers an essential guide to one of the truly life-or-death issues of our age. In concise, question-and-answer format, he explains the causes of pandemics, how they can be counteracted with vaccines and drugs, and how we can better prepare for them in the future. Doherty notes that the term "pandemic" refers not to a disease's severity but to its ability to spread rapidly over a wide geographical area. Extremely lethal pathogens are usually quickly identified and confined. Nevertheless, the rise of high-speed transportation networks and the globalization of trade and travel have radically accelerated the spread of diseases. A traveler from Africa arrived in New York in 1999 carrying the West Nile virus; one mosquito bite later, it was loose in the ecosystem. Doherty explains how the main threat of a pandemic comes from respiratory viruses, such as influenza and SARS, which disseminate with incredible speed through air travel. The climate disruptions of global warming, rising population density, and growing antibiotic resistance all complicate efforts to control pandemics. But Doherty stresses that pandemics can be fought effectively. Often simple health practices, especially in hospitals, can help enormously. And research into the animal reservoirs of pathogens, from SARS in bats to HIV in chimpanzees, show promise for our prevention efforts.

Calm, clear, and authoritative, Peter Doherty's Pandemics is one of the most critically important additions to the What Everyone Needs to Know® series.

What Everyone Needs to Know® is a registered trademark of Oxford University Press.

1.Historical perspective 2.Respiratory infections: the greatest danger 3.Bats, birds and wildlife reservoirs 4.Continuing pandemics 5.Climate change and global warming 6.Vaccines 7.Drugs 8.Monoclonal antibodies 9.Quarantine and restrictions on human movement 10.Strategic planning and timing

Peter C. Doherty , Australia

Peter C. Doherty is Chairman of the Department of Immunology at St. Jude's Children's Research Hospital, and a Laureate Professor of Microbiology and Immunology at the University of Melbourne. He is the author of The Beginner's Guide to Winning the Nobel Prize: Advice for Young Scientists, Their Fate is Our Fate: How Birds Foretell Threats to Our Health and Our World, published in Australia as Sentinel Chickens: What Birds Tell us About Our health and the World; and A Light History of Hot Air.

"A gem of a book... Relevant biological, epidemiological and political concepts are explained and scientific cant illuminated in Q and A diversions.These include a most clear and pertinent précis of what immunity means, which is no mean feat. At the same time Doherty is not above asking (and then answering) earthier questions such as: 'What is snot?'" - Adam Jenney, COSMOS Magazine